"Nourishing European Interest Groups: The Delors Commission and Labour"

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Whirl and Stall Flutter Simulation Using CFD

This paper presents recent research on numerical methods for whirl and stall flutter using computational fluid dynamics. The method involves coupling of the HMB3 CFD solver of the University of Glasgow and a NASTRAN derived structural model. Based upon a literature survey, a significant amount of research has been conducted on the numerical investigation of tiltrotors, with a focus on the XV-15 and V-22 aircraft. Within this paper, the coupling procedure is presented along with a steady CFD computation to highlight the accuracy of the high-fidelity method. In addition to this, a simple method is used to investigate the whirl flutter boundary of a standard propeller and the XV-15 blade

Qualitative System Identification from Imperfect Data

Experience in the physical sciences suggests that the only realistic means of understanding complex systems is through the use of mathematical models. Typically, this has come to mean the identification of quantitative models expressed as differential equations. Quantitative modelling works best when the structure of the model (i.e., the form of the equations) is known; and the primary concern is one of estimating the values of the parameters in the model. For complex biological systems, the model-structure is rarely known and the modeler has to deal with both model-identification and parameter-estimation. In this paper we are concerned with providing automated assistance to the first of these problems. Specifically, we examine the identification by machine of the structural relationships between experimentally observed variables. These relationship will be expressed in the form of qualitative abstractions of a quantitative model. Such qualitative models may not only provide clues to the precise quantitative model, but also assist in understanding the essence of that model. Our position in this paper is that background knowledge incorporating system modelling principles can be used to constrain effectively the set of good qualitative models. Utilising the model-identification framework provided by Inductive Logic Programming (ILP) we present empirical support for this position using a series of increasingly complex artificial datasets. The results are obtained with qualitative and quantitative data subject to varying amounts of noise and different degrees of sparsity. The results also point to the presence of a set of qualitative states, which we term kernel subsets, that may be necessary for a qualitative model-learner to learn correct models. We demonstrate scalability of the method to biological system modelling by identification of the glycolysis metabolic pathway from data

A Preliminary Analysis of the Benefits of Introducing Apomixis into Rice

The objective of this research is to undertake an ex ante economic analysis of basic scientific research that aims to identify the gene(s) that control apomictic reproduction, with the ultimate aim of transferring the characteristic into commercially important crops. This paper reports very preliminary results, using the introduction of apomixis into rice as a case study. Apomixis is a natural, asexual method of plant reproduction resulting in offspring that are genetically identical to the mother plant. Apomixis promises to revolutionize plant breeding by providing a system for crop improvement that allows any desired variety, including hybrids, to breed true. This ability will make both breeding and seed production more efficient. It offers the opportunity for plant breeders to more readily develop varieties that are specifically adapted to local conditions, using, and thus conserving, greater genetic diversity. Apomixis will also allow resource-poor farmers to replant the seed they produce from locally bred varieties year after year, a strategy not possible with today's commercial hybrid varieties. Global changes in aggregate welfare, resource allocation, production and price levels are calculated using the global economy-wide computable general equilibrium model known as GTAP. Preliminary modeling results suggest that the overall welfare gains associated apomictic rice could be substantial.Agribusiness, Agricultural and Food Policy, Crop Production/Industries, Environmental Economics and Policy, Farm Management, Institutional and Behavioral Economics, Land Economics/Use, Production Economics, Research Methods/ Statistical Methods,

Embryonic POU5F1 is Required for Expanded Bovine Blastocyst Formation.

POU5F1 is a transcription factor and master regulator of cell pluripotency with indispensable roles in early embryo development and cell lineage specification. The role of embryonic POU5F1 in blastocyst formation and cell lineage specification differs between mammalian species but remains completely unknown in cattle. The CRISPR/Cas9 system was utilized for targeted disruption of the POU5F1 gene by direct injection into zygotes. Disruption of the bovine POU5F1 locus prevented blastocyst formation and was associated with embryonic arrest at the morula stage. POU5F1 knockout morulas developed at a similar rate as control embryos and presented a similar number of blastomeres by day 5 of development. Initiation of SOX2 expression by day 5 of development was not affected by lack of POU5F1. On the other hand, CDX2 expression was aberrant in embryos lacking POU5F1. Notably, the phenotype observed in bovine POU5F1 knockout embryos reveals conserved functions associated with loss of human embryonic POU5F1 that differ from Pou5f1- null mice. The similarity observed in transcriptional regulation of early embryo development between cattle and humans combined with highly efficient gene editing techniques make the bovine a valuable model for human embryo biology with expanded applications in agriculture and assisted reproductive technologies